我正在尝试用ode45模拟神经元的Morris-Lecar模型。
我在初始化ode45调用时遇到了问题,文档也无法帮助我。我知道我必须通过一个函数调用ode45,然后从我的主脚本调用该函数。
一般来说,我对ODE的掌握有限,而且似乎难以理解初始化ODE45-call所需的语法。
此外,我被指示为变量'pulse‘使用时间范围,但函数中没有时间范围的输入(似乎是一个变量,而不是固定的),该函数从主脚本接收输入,并将其与其他函数一起发送到ode45函数。提供给ode45的函数也有时间输入,但是我还是不知道如何输入时间范围。说明非常清楚,主脚本中使用的函数不接受任何时间变量。
如果您能指出我在初始化过程中所犯的任何明显错误,我们将不胜感激。
当前(下)版本的错误码如下:
Error using ODEequation (line 89)
Not enough input arguments.
Error in odearguments (line 88)
f0 = feval(ode,t0,y0,args{:}); % ODE15I sets args{1} to yp0.
Error in ode45 (line 114)
[neq, tspan, ntspan, next, t0, tfinal, tdir, y0, f0, odeArgs, odeFcn, ...
Error in ODEquestion (line 32)
[t Vm]=ode45(@ODEequation,[-20 20],[-30, 0.1]',[],constants, stim_on, stim_off, amp);
Error in YoonS_Lab3_EBME308_Fall2012 (line 355)
[t Vm] = ODEquestion(20,100,30)我想这可以追溯到我不存在的,但需要时间的投入。
问题涉及到
Cm * dVm / dt = -Gm(Vm-Vrest) - Gca Minf (Vm - Eca) - Gk w(Vm - Ek) + pulse(t)
dw/dt = (wInf - w) / Tau-w;
wInf = (1+tanh(Vm/30)) / 2;
mInf = (1+tanh(Vm+1)) / 2;
Tau-w = 5/ (cosh(Vm/60));
Cm = membrane leakage capacticance;
Gm = membrane leakage conductance;
Vm = membrane voltage;
Vrest = membrane voltage @ neuron resting
Gca = max Ca conductance through membrane
Gk = max K conductance through membrane;
mInf refers = P ( Ca ion channel open )
wInf refers = P ( K ion channel open )
Tau-w = rate which K channels respond to change in membrane voltage
Eca = reversal potential of Ca
Ek = reversal potential of K
pulse(t) = stimulus applied to neuron
pulse(t) = A (stim-on <= t <= stim-off) or 0 (else);作为变量。
我已经创建了一个发送到ode45的函数,如下所示。
function dy = ODEequation(t, Vm, w, constants, stim_on, stim_off, amp)
wInf = (1 + tan(Vm / 30)) / 2
mInf = (1 + tan((Vm + 1)/ 15)) / 2
tauW = 5/ (cosh(Vm/60))
pulse = amp * ((stim_on < t ) - ( t >= stim_off));
dy(1) = y(1) * ((-constants(2) - constants(4) * constants(9) - constants(5) * y(2)) + (constants(2) * constants(3) + constants(6) * constants(4) * constants(9) + constants(5) * y(2) * constants(7) + constants(11))) / constants(1) ;
dy(2) = = ( constants(8) - y(2) )/constants(10)
dy = dy'传递的函数如下所示
function [t Vm] = ODEquestion(stim_on, stim_off, amp)
%i)
Cm = 1;
Gm = 0.5;
Vrest = -50;
Gca = 1.1;
Gk = 2;
Eca = 100;
Ek = -70;
%ii)
Vm(1) = -30;
w(1) = 0.1;
%iii)
wInf = (1 + tan(Vm / 30)) / 2
mInf = (1 + tan((Vm + 1)/ 15)) / 2
tauW = 5/ (cosh(Vm/60))
IC1 = Vm(1) % = -30
IC2 = w(1) % = 0.1
pulse = amp %* ((stim_on < t ) - ( t >= stim_off));
constants = [Cm , Gm, Vrest, Gca, Gk, Eca, Ek, wInf, mInf, tauW, pulse];
[t Vm]=ode45(@ODEequation,[-20 20],[-30, 0.1]',[],constants, stim_on, stim_off, amp);发布于 2012-10-04 14:19:13
来自help ode45:
ODE45解非刚性微分方程,中阶方法。
TOUT,YOUT = ODE45(ODEFUN,TSPAN,Y0)与TSPAN = T0 TFINAL在初始条件Y0下积分从时间T0到TFINAL的微分方程组y‘= f(t,y)。ODEFUN是一个函数句柄。对于标量T和向量Y,ODEFUN(T,y)必须返回对应于f(t,Y)的列向量。
因此,函数ODEFUN只需要两个输入(t和y),而您的函数需要7个输入。
您可以通过遵循this site或this question上的说明来解决此问题:
wrapper = @(t,Vm) ODEequation(t, Vm, w, constants, stim_on, stim_off, amp);
[t Vm]=ode45(wrapper, [-20 20],[-30, 0.1]',[],constants, stim_on, stim_off, amp);例如,通过创建传递所有常量的小包装函数,同时转发由ode45插入的变量。
https://stackoverflow.com/questions/12720549
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